Products & Services
CMP Scientific's EMASS-II Capillary Electrophoresis - Mass Spectrometry (CE-MS) coupling ion source uses an electrokinetically pumped sheath liquid nanospray ionization technology, which greatly enhances the overall performance of CE-MS analysis. The EMASS-II ion source not only improves CE-MS sensitivity by several orders of magnitude, but also, for the first time, enables online cIEF-MS analysis for direct identification of charge variants of protein biotherapeutics. With the unprecedented amount of biologics emerging in early phase and preclinical development, CMP Scientific's EMASS-II CE-MS technology is making a difference in therapeutic protein drug development worldwide.
ECE-001 Capillary Electrophoresis
CMP Scientific's ECE-001 CE system is designed for the coupling with mass spectrometry. It offers separate temperature controls on the sample and buffer trays. A minimum length of 50 cm separation capillary may be used on ECE-001 CE unit for both CZE-MS and cIEF-MS analysis.
EMASS-II CE-MS Ion Source
CMP Scientific's EMASS-II CE-MS ion source has been designed with mounting stages for common ESI mass spectrometers. Both positive and negative CE-MS modes are supported by EMASS-II ion source. Numerous applications have been developed using EMASS-II CE-MS ion source, including proteomics, polysaccharide analysis, monoclonal antibody intact molecule and subunits analysis, fusion protein biotransformation, and charge variants analysis by online cIEF-MS.
EMAST-A CE-ESI-TOF System
CMP Scientific develops and manufactures fully integrated capillary electrophoresis - mass spectrometry system, utilizing its patented EMASS-II CE-MS coupling technology.
In general, many proteins, such as therapeutic monoclonal antibodies (mAbs), have charge variants. Based on the eminent EMASS-II CE-MS technology, CMP Scientific has realized automatic online MS analysis of antibody drug charge variants, which greatly improves the efficiency and accuracy of detection. So far, we have used the online cIEF-MS to complete numerous successful cases of charge variants characterization of protein drugs, including mAbs, bispecific antibodies, fusion proteins, ADC drugs.
For more information about our CE-MS services, please visit our service website, chargevariants.com.
CR3520 cIEF-MS Reagent Kit
CMP Scientific's CR3520 cIEF-MS reagent kit enables fully automated online charge variants analysis for recombinant protein therapeutics. Excellent resolution and assay robustness have been demonstrated over 100 repeat injections of cIEF-MS analyses.
CMP Scientific provides a wide set of consumables, providing options for various analytical purposes. The proprietary coating and manufacturing process contributes to the desirable results for cIEF-MS and CZE-MS analysis.